Current Neuropharmacology· 2015Q1· Review
The Effects of Psychological Stress on Depression
- 601citations
- Q1SCImago
- 2015year
Short summary
Psychological stress significantly influences the development and progression of major depressive disorder, with emerging animal models and research elucidating underlying physiopathology.
AI-generated from the title and abstract; the full text is not read.
Key points
- Psychological stress is increasingly recognized as a key factor in the development of major depressive disorder.
- Animal models, though limited, are crucial for understanding the physiopathology of stress-induced depression.
- Research is advancing our knowledge of the biological mechanisms underlying depression.
- Novel methods are being developed to study and potentially treat depressive symptoms.
AI-generated from the title and abstract; the full text is not read.
Abstract
Major depressive disorder is a serious mental disorder that profoundly affects an individual's quality of life. Although the aetiologies underlying this disorder remain unclear, an increasing attention has been focused on the influence imposed by psychological stress over depression. Despite limited animal models of psychological stress, significant progress has been made as to be explicated in this review to elucidate the physiopathology underlying depression and to treat depressive symptoms. Therefore, we will review classical models along with new methods that will enrich our knowledge of this disorder. Keywords: Brain-derived neurotrophic factor, depression, glial cell-derived neurotrophic factor, hippocampus, nucleus accumbens, prefrontal cortex, psychological stress, ventral tegmental area.
The authors' abstract, as published at the source. Current Neuropharmacology, 2015 · DOI ↗
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Field: Behavioral Neuroscience
Behavioral NeuroscienceNeuroscience