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Brain Behavior and Immunity· 2020Q1· Review

Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls

Emanuele F. Osimo, Toby Pillinger, Irene Mateos Rodríguez, Golam M. Khandaker et al.

Short summary

This meta-analysis of 107 studies (5,166 depressed patients, 5,083 controls) confirms depression is a pro-inflammatory state, with significantly elevated levels of key markers like CRP, IL-6, and TNFα.

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Field: Biological Psychiatry

Biological PsychiatryNeuroscience