Molecular Psychiatry· 2022Q1· Review

The Serotonin Theory of Depression: A Systematic Umbrella Review of the Evidence

Joanna Moncrieff, Ruth Cooper, Tom Stockmann, Simone Amendola et al.

900citations
Q1SCImago
2022year

Short summary

This umbrella review found no consistent evidence supporting the serotonin theory of depression, which posits that depression is caused by lowered serotonin activity or concentrations.

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Field: Biological Psychiatry

Biological PsychiatryNeuroscience