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Psychological Bulletin· 2014Q1· Review

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

George M. Slavich, Michael R. Irwin

Short summary

This review proposes a new theory linking social stress to depression through inflammation, suggesting that social threats activate immune responses, leading to proinflammatory cytokines that drive depressive symptoms.

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Field: Biological Psychiatry

Biological PsychiatryNeuroscience