Journal of Neuroinflammation· 2013Q1
Neuroinflammation and psychiatric illness
- 736citations
- Q1SCImago
- 2013year
Short summary
Neuroinflammation, particularly from under-recognized synaptic autoimmune encephalitides, plays a pathogenic role in psychiatric disorders, challenging traditional neurotransmitter-focused explanations.
AI-generated from the title and abstract; the full text is not read.
Key points
- Neuroinflammation is increasingly recognized as a pathogenic factor in psychiatric disorders.
- Synaptic autoimmune encephalitides with psychotic symptoms are often under-diagnosed.
- Neuroimmunological abnormalities are observed in major depressive, bipolar, schizophrenia, and obsessive-compulsive disorders.
- Understanding the interplay of genetic, immune, and neurotransmitter systems is key for new therapies.
AI-generated from the title and abstract; the full text is not read.
Abstract
Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric symptoms and autoimmunity in autoimmune diseases, neuroimmunological abnormalities occur in classical psychiatric disorders (for example, major depressive, bipolar, schizophrenia, and obsessive-compulsive disorders). Investigations into the pathophysiology of these conditions traditionally stressed dysregulation of the glutamatergic and monoaminergic systems, but the mechanisms causing these neurotransmitter abnormalities remained elusive. We review the link between autoimmunity and neuropsychiatric disorders, and the human and experimental evidence supporting the pathogenic role of neuroinflammation in selected classical psychiatric disorders. Understanding how psychosocial, genetic, immunological and neurotransmitter systems interact can reveal pathogenic clues and help target new preventive and symptomatic therapies.
The authors' abstract, as published at the source. Journal of Neuroinflammation, 2013 · DOI ↗
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Field: Biological Psychiatry
Biological PsychiatryNeuroscience