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JAMA Psychiatry· 2015Q1

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

Elaine Setiawan, Alan A. Wilson, Romina Mizrahi, Pablo Rusjan et al.

Short summary

Major depressive episodes (MDE) are associated with a 26-33% increase in translocator protein density (TSPO VT), a marker of microglial activation, in key brain regions like the prefrontal cortex, anterior cingulate cortex (ACC), and insula.

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Field: Biological Psychiatry

Biological PsychiatryNeuroscience