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Science· 2017Q1

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

Juan L. Gomez, Jordi Bonaventura, Wojciech G. Lesniak, William B. Mathews et al.

Short summary

Clozapine, not clozapine N-oxide (CNO), is the active metabolite that binds to and activates DREADDs in the brain after systemic CNO injection.

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Field: Cellular and Molecular Neuroscience

Cellular and Molecular NeuroscienceNeuroscience