Neurosignals· 2012Q4
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
- 3,394citations
- Q4SCImago
- 2012year
Short summary
Insulin and leptin activate mTORC1 signaling, suppressing appetite, while ghrelin activates AMPK, promoting appetite and increasing AgRP mRNA. mTORC1 integrates these opposing hormonal signals in hypothalamic neurons.
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Endocrine and Autonomic SystemsNeuroscience