Endocrine and Autonomic Systems papers

Pofolia’s corpus holds 51 papers from Endocrine and Autonomic Systems (2012–2025), each with a short summary. Below, the 20 most-cited, then the most recently added.

At a glance

• Most cited: Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression (2012, 3,394 citations).
• The 20 papers listed have 27,946 citations between them.
• 18 of the 20 with a known journal quartile appeared in a Q1 journal.
• 13 have a free full text (open access).
• Most frequent journals: Journal of Pineal Research, Science, Proceedings of the National Academy of Sciences.
• Published between 2012 and 2021.

Most cited

Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”. How to read the signals

• Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

  Neurosignals · 2012 · Q4 · FWCI 78.46 · 3,394 citations · Open access

  Insulin and leptin activate mTORC1 signaling, suppressing appetite, while ghrelin activates AMPK, promoting appetite and increasing AgRP mRNA. mTORC1 integrates these opposing hormonal signals in hypothalamic neurons.

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• A circadian gene expression atlas in mammals: Implications for biology and medicine

  Proceedings of the National Academy of Sciences · 2014 · Q1 · SJR 3.00 · FWCI 46.20 · 2,406 citations · Open access

  Researchers mapped circadian gene expression across 12 mouse organs, revealing that 43% of protein-coding genes exhibit rhythmic transcription, often peaking before dawn and dusk.

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• Central and Peripheral Circadian Clocks in Mammals

  Annual Review of Neuroscience · 2012 · Q1 · SJR 7.00 · FWCI 37.25 · 2,264 citations

  Mammals possess a hierarchical system of circadian clocks, with a central master pacemaker in the brain's SCN and cell-autonomous clocks throughout the body that are deeply integrated with metabolic pathways.

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• The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

  Nature Communications · 2014 · Q1 · SJR 4.00 · FWCI 25.03 · 1,749 citations · Open access

  Dietary acetate, produced by gut bacteria fermenting carbohydrates, crosses the blood-brain barrier and directly suppresses appetite by activating specific hypothalamic neurons.

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• Melatonin as an antioxidant: under promises but over delivers

  Journal of Pineal Research · 2016 · Q1 · SJR 1.00 · FWCI 64.84 · 1,682 citations · Open access

  Melatonin is an exceptionally effective antioxidant, acting directly on reactive species and indirectly via antioxidant enzymes, with a notable presence in mitochondria that enhances its protective capabilities.

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• Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

  Science · 2018 · Q1 · SJR 10.00 · FWCI 49.29 · 1,532 citations

  Researchers have created a high-resolution, spatially mapped atlas of the mouse hypothalamic preoptic region by profiling nearly 1 million cells, identifying ~70 distinct neuronal populations.

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• Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

  Science · 2012 · Q1 · SJR 10.00 · FWCI 31.63 · 1,502 citations

  Mammalian circadian clocks exhibit a three-phase transcriptional cycle (poised, activation, repressed) involving CLOCK/BMAL1, with only 22% of cycling mRNAs driven by new transcription, suggesting significant post-transcriptional regulation.

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• Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness

  Proceedings of the National Academy of Sciences · 2014 · Q1 · SJR 3.00 · FWCI 25.75 · 1,374 citations · Open access

  Reading on a light-emitting eReader (LE-eBook) before bed delays sleep onset, reduces evening sleepiness, and suppresses melatonin compared to reading a printed book.

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• Circadian Typology: A Comprehensive Review

  Chronobiology International · 2012 · Q2 · FWCI 19.84 · 1,362 citations

  Circadian typology (CT), representing individual differences in daily biological rhythms, significantly impacts psychological and biological functioning across health and disease.

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• Energy Balance and Obesity

  Circulation · 2012 · Q1 · SJR 8.00 · FWCI 14.77 · 1,297 citations · Open access

  Reducing obesity necessitates modifying both energy intake and expenditure, as physiology favors energy balance at a high flux, which in sedentary environments leads to weight gain.

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• Circadian physiology of metabolism

  Science · 2016 · Q1 · SJR 10.00 · FWCI 30.38 · 1,080 citations · Open access

  Circadian rhythms, driven by daily light-dark and feeding-fasting cycles, regulate the expression of most mammalian genes and optimize physiology by managing energy use and separating incompatible processes.

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• Leptin and Obesity: Role and Clinical Implication

  Frontiers in Endocrinology · 2021 · Q1 · SJR 1.00 · FWCI 60.29 · 1,075 citations · Open access

  Leptin, a hormone produced by fat cells, regulates appetite and body mass, but resistance to its effects often leads to obesity and reduces its therapeutic effectiveness.

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• Ghrelin

  Molecular Metabolism · 2015 · Q1 · SJR 2.00 · FWCI 40.72 · 1,012 citations

  Ghrelin, a gastrointestinal hormone, has demonstrated a wide range of central and peripheral actions beyond its known role in energy metabolism.

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• Circadian rhythm disruption and mental health

  Translational Psychiatry · 2020 · Q1 · SJR 2.00 · FWCI 40.42 · 997 citations · Open access

  Disrupted circadian rhythms, influenced by factors like shift work and artificial light, are strongly linked to mood disorders. Recent research is beginning to uncover the direct molecular and neural pathways connecting the body's internal clock to mood regulation.

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• Melatonin: an ancient molecule that makes oxygen metabolically tolerable

  Journal of Pineal Research · 2015 · Q1 · SJR 1.00 · FWCI 46.49 · 949 citations · Open access

  This paper hypothesizes that melatonin's original and primary function, emerging 3.5-3.2 billion years ago in cyanobacteria, was as an antioxidant to counteract toxic free radicals produced by photosynthesis.

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• Functions of melatonin in plants: a review

  Journal of Pineal Research · 2015 · Q1 · SJR 1.00 · FWCI 22.83 · 886 citations

  Melatonin, a molecule with known functions in animals, exhibits significant potential in plant physiology, acting as a key antistress agent and regulator of plant development.

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• Mechanisms linking circadian clocks, sleep, and neurodegeneration

  Science · 2016 · Q1 · SJR 10.00 · FWCI 26.31 · 875 citations

  Circadian and sleep disturbances, often seen as symptoms of neurodegenerative diseases like Alzheimer's, may actually drive their early development. This review explores the cellular and molecular links between disrupted biological clocks, poor sleep, and the progression of these conditions.

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• The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

  International Journal of Obesity · 2014 · Q1 · SJR 1.00 · FWCI 15.76 · 844 citations · Open access

  The short chain fatty acid propionate directly stimulates the release of appetite-suppressing gut hormones GLP-1 and PYY in rodents. This effect is mediated by the free fatty acid receptor 2 (FFA2) on gut cells.

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• New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

  British Journal of Pharmacology · 2018 · Q1 · SJR 2.00 · FWCI 22.90 · 837 citations · Open access

  Melatonin, produced by the brain's central clock, signals darkness and induces night-time functions like sleep and lower blood pressure. New research highlights its potential for early intervention in Alzheimer's disease and promoting healthy aging.

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• Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions

  Journal of Pineal Research · 2014 · Q1 · SJR 1.00 · FWCI 31.28 · 829 citations · Open access

  Melatonin, a well-known antioxidant, can act as a pro-oxidant at high concentrations by promoting reactive oxygen species (ROS) generation, potentially through interactions with calmodulin or mitochondria.

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Recently added

• Role of Circadian Health in Cardiometabolic Health and Disease Risk: A Scientific Statement From the American Heart Association

  Circulation · 2025 · Q1 · SJR 8.00 · FWCI 23.50 · 57 citations · Open access

  Circadian rhythm disruptions negatively impact heart and metabolic health, increasing risks for obesity, type 2 diabetes, hypertension, and cardiovascular disease.

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• Cognitive functions and underlying parameters of human brain physiology are associated with chronotype

  Nature Communications · 2021 · Q1 · SJR 4.00 · FWCI 8.26 · 156 citations · Open access

  Human chronotype (being a morning or evening person) is associated with enhanced motor learning, working memory, and attention at one's preferred time of day, driven by increased cortical excitability and neuroplasticity.

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• Leptin and Obesity: Role and Clinical Implication

  Frontiers in Endocrinology · 2021 · Q1 · SJR 1.00 · FWCI 60.29 · 1,075 citations · Open access

  Leptin, a hormone produced by fat cells, regulates appetite and body mass, but resistance to its effects often leads to obesity and reduces its therapeutic effectiveness.

  Go to source →

• Circadian rhythm disruption and mental health

  Translational Psychiatry · 2020 · Q1 · SJR 2.00 · FWCI 40.42 · 997 citations · Open access

  Disrupted circadian rhythms, influenced by factors like shift work and artificial light, are strongly linked to mood disorders. Recent research is beginning to uncover the direct molecular and neural pathways connecting the body's internal clock to mood regulation.

  Go to source →

• Effects of light on human circadian rhythms, sleep and mood

  Somnologie - Schlafforschung und Schlafmedizin · 2019 · Q4 · FWCI 15.82 · 663 citations · Open access

  Artificial light, especially at night, disrupts human circadian rhythms and sleep, potentially increasing the risk of sleep disorders, but light can also be used therapeutically to improve sleep and mood.

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• Chronotype and Social Jetlag: A (Self-) Critical Review

  Biology · 2019 · Q1 · FWCI 23.53 · 686 citations · Open access

  The Munich ChronoType Questionnaire (MCTQ), a widely used tool for assessing chronotype and social jetlag, is critically reviewed after 15 years of use and over 1200 citations.

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• Melatonin Synthesis and Function: Evolutionary History in Animals and Plants

  Frontiers in Endocrinology · 2019 · Q1 · SJR 1.00 · FWCI 28.69 · 694 citations · Open access

  Melatonin, an ancient molecule originating in bacteria, has retained its antioxidant function throughout evolution, now synthesized in mitochondria (animals/plants) and chloroplasts (plants) and acting via receptor-independent pathways.

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• Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

  Nature Communications · 2019 · Q1 · SJR 4.00 · FWCI 31.17 · 732 citations · Open access

  Genome-wide association analyses in 697,828 individuals identified 351 genetic loci linked to chronotype (being a morning person), a 14-fold increase from previous findings.

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Journals in this field

The journals that publish most of this field’s papers. Quartile (Q1–Q4), SJR and h-index are from SCImago Journal Rank; “in this field” is how many of the journal’s pooled papers belong here. What is a Q1 journal? · What is the h-index?

Every journal in Endocrine and Autonomic Systems (Q1–Q4) →

Other subfields in Neuroscience

• Cognitive Neuroscience
• Biological Psychiatry
• Behavioral Neuroscience
• Sensory Systems
• Developmental Neuroscience
• Cellular and Molecular Neuroscience
• Neurology (Neuroscience)

All subfields of Neuroscience →

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