Stroke· 2012Q1

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

Xiaoming Hu, Peiying Li, Yanling Guo, Haiying Wang et al.

1,584citations
Q1SCImago
2012year

Short summary

Microglia and macrophages initially adopt a protective M2 phenotype after ischemic stroke, but later shift to a detrimental M1 phenotype in peri-infarct regions, exacerbating neuronal death.

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Field: Neurology (Neuroscience)

NeurologyNeuroscience