MR Sitometri Meme Kanserinde Mikro Yapısal Değişiklikleri İzleyerek Tedavi Yanıtını ve Prognozu Tahmin Ediyor

Özet (abstract)

ABSTRACT Background Although MR cytometry can probe microstructural features, the longitudinal trajectories of these changes during neoadjuvant chemotherapy (NAC) and their association with treatment response and prognosis remain poorly defined. Purpose To characterize longitudinal changes in NAC‐associated cellular microstructural properties and evaluate microstructural parameters for predicting pathologic complete response (pCR) and disease‐free survival (DFS) in breast cancer. Study Type Prospective. Population 194 patients with invasive breast cancer underwent 713 MRI examinations. Field Strength/Sequence 3.0 T, oscillating gradient spin‐echo (OGSE) and pulsed gradient spin‐echo (PGSE) sequences. Assessment MR cytometry was acquired at four time‐points: pretreatment, early, mid‐, and late treatment. Microstructural parameters were estimated using the IMPULSED (imaging microstructural parameters using limited spectrally edited diffusion) model. Microstructural parameters were compared with histopathologic measurements. Statistical Tests Generalized estimating equations, logistic regression, bootstrap resampling, the DeLong test with Bonferroni correction, Cox proportional hazards regression, Kaplan–Meier analysis with the log‐rank test, the C‐index, and the Pearson correlation coefficient were performed. p < 0.05 was significant. Results Four logistic regression models were developed for predicting pCR, based on molecular subtype alone or combined with diameter at Time 1, ADC 50Hz at Time 2, or cellularity at Time 2. The clinicopathological–cellularity model achieved the best performance in predicting pCR (AUC = 0.89). For DFS, a Cox model incorporating ER status, HER2 status, cT stage, cN stage, and extracellular diffusivity at Time 1 yielded a C‐index of 0.81; patients stratified by the median risk score into low‐ and high‐risk groups differed significantly in DFS. Extracellular diffusion was positively correlated with pathologic stroma fraction ( r = 0.56). Data Conclusion MR cytometry demonstrated longitudinal microstructural alterations during NAC and shows potential for predicting pCR and stratifying patients by DFS risk in breast cancer patients. Level of Evidence 1. Technical Efficacy Stage 2.

Yazarların özeti; kaynağından alınmıştır. Journal of Magnetic Resonance Imaging, 2026 · DOI ↗