Flavour and Fragrance Journal· 2026Q2
Phytochemical Investigation and In Vitro Assessment of Antioxidant, Anti‐Inflammatory and Immunomodulatory Properties of Melia azedarach Linn. Extract in Chicken Lymphocyte Model
- 0citations
- Q2SCImago
- 2026year
Short summary
A 50% hydromethanolic extract of Melia azedarach (MAE) leaves demonstrated significant antioxidant, anti-inflammatory, and immunomodulatory activity in chicken lymphocytes, as shown by in vitro assays.
AI-generated from the title and abstract; the full text is not read.
Key points
- Melia azedarach leaf extract (MAE) was prepared using a 50% hydromethanolic solvent.
- MAE exhibited significant antioxidant and anti-inflammatory properties in vitro.
- MAE demonstrated immunomodulatory potential by enhancing lymphocyte proliferation and altering cytokine gene expression in chicken lymphocytes.
- The Maximum Non-Cytotoxic Dose (MNCD) of MAE was determined using MTT assay.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Melia azedarach Linn. (chinaberry), a medicinal plant native to tropical Asia, is a rich source of diverse bioactive compounds with reported pharmacological activities and promising therapeutic potential. Despite its recognized phytochemical richness and biological properties, its bioactive composition and functional attributes remain insufficiently characterized. The objective of this study was to explore the phytochemical composition of M. azedarach Linn. leaves and evaluate its antioxidative, anti‐inflammatory and immunomodulatory potential in chicken lymphocytes. The leaves of the plant were collected and 50% hydromethanolic extract of M. azedarach (L.) was prepared (MAE) which was subjected to explore its antioxidative and anti‐inflammatory properties through various in vitro assays. MTT assay was conducted to assess the Maximum Non‐Cytotoxic Dose (MNCD) of MAE. The immunomodulatory potential of MAE was assessed by Lymphocyte Proliferation Assay (LPA) and further confirmed through altered expression of cytokine genes via quantitative Reverse Transcription‐PCR (qRT‐PCR). The obtained results demonstrated significant antioxidative, anti‐inflammatory and immunomodulatory activity of MAE in chicken lymphocytes. Further in vitro and in vivo studies are recommended to explore MAE's potential as a plant‐based therapeutic agent for immunomodulation.
The authors' abstract, as published at the source. Flavour and Fragrance Journal, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Complementary and alternative medicine
Complementary and alternative medicineMedicine