iScience· 2026Q1
Hyperglycemia induces endothelial mitochondrial dysfunction and myeloperoxidase dysregulation in PCOS iPSCs
- 0citations
- Q1SCImago
- 2026year
Short summary
PCOS patient-derived endothelial cells (iPSC-ECs) show impaired angiogenesis and mitochondrial fragmentation under hyperglycemia, linked to aberrant myeloperoxidase (MPO) expression.
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Key points
- PCOS iPSC-derived endothelial cells (iPSC-ECs) show impaired angiogenesis and mitochondrial fragmentation when exposed to hyperglycemia.
- Hyperglycemia causes bioenergetic impairment and aberrant intracellular myeloperoxidase (MPO) expression in PCOS iPSC-ECs.
- Elevated systemic MPO levels in women with PCOS correlate with diastolic blood pressure, glucose levels, and LDLs.
- Findings suggest an intrinsic metabolic-oxidative defect in the PCOS endothelium triggered by hyperglycemia.
AI-generated from the title and abstract; the full text is not read.
Abstract
Polycystic ovary syndrome (PCOS) is associated with increased risks of cardiovascular disease (CVD), driven in part by endothelial dysfunction. Using patient-derived induced pluripotent stem cells (iPSCs), we established an endothelial model to examine cellular responses to metabolic stress independent of the complex systemic environment. We demonstrate that PCOS iPSC-derived endothelial cells (PCOS iPSC-ECs) exhibit a disease-specific susceptibility to hyperglycemia, resulting in impaired angiogenesis, mitochondrial fragmentation, and bioenergetic impairment. This stress-induced injury is accompanied by aberrant intracellular myeloperoxidase (MPO) expression. Consistent with these findings, clinical data revealed elevated systemic MPO levels in women with PCOS that correlate with diastolic blood pressure (DBP), glucose levels, and low-density lipoproteins (LDLs). Our results identify an intrinsic metabolic-oxidative defect, a latent mitochondrial vulnerability triggered by hyperglycemic stress, in the PCOS endothelium. These findings position MPO as a potential biomarker and putative mediator for cardiovascular risk stratification in PCOS.
The authors' abstract, as published at the source. iScience, 2026 · DOI ↗
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Field: Reproductive Medicine
Reproductive MedicineMedicine