Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

Short summary

Polycystic ovary syndrome (PCOS) is a significant metabolic disorder, not just reproductive, with a substantially increased risk for type 2 diabetes, even in lean women. A key mechanism involves a post-binding defect in insulin receptor signaling, specifically increased serine phosphorylation of the receptor and IRS-1, which impairs metabolic actions without affecting mitogenic pathways.

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