PLoS Biology· 2026Q1
Cellular diversity in neural organoids is critical for neurodegenerative disease modeling
- 0citations
- Q1SCImago
- 2026year
Short summary
Neural organoids must include immune and vascular cells to accurately model neurodegenerative diseases, as these cell types are fundamental to neuroinflammation and vascular dysfunction, hallmarks of these conditions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Neuroinflammation and vascular dysfunction are central to most neurodegenerative diseases.
- Immune and vascular cells are therefore fundamental components for neurodegenerative disease models.
- These cell types should be considered essential, not optional, in organoid development for this purpose.
AI-generated from the title and abstract; the full text is not read.
Abstract
Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune, and vascular cells should therefore be considered fundamental components, rather than optional additions.
The authors' abstract, as published at the source. PLoS Biology, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience