Medical Epigenetics· 2016· Review
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
- 8,960citations
- 2016year
Short summary
This review highlights how epigenetic mechanisms like histone modifications, chromatin looping, and gene methylation regulate GABAergic neurotransmission, which is crucial for brain development and function.
AI-generated from the title and abstract; the full text is not read.
Key points
- GABAergic neurotransmission is vital for neurogenesis, neuronal migration, and synaptogenesis.
- Epigenetic mechanisms (histone modification, methylation, chromatin looping) control GABAergic gene expression.
- Dysregulation of these epigenetic processes contributes to neurological disorders including autism, Rett's syndrome, and schizophrenia.
- Understanding these epigenetic links offers potential for developing novel epigenetic therapies for neurological diseases.
AI-generated from the title and abstract; the full text is not read.
Abstract
The GABAergic neurotransmission is a highly conserved system that has been attributed to various regulatory events. There has been a notable number of studies on the importance of GABAergic neurotransmission, both excitatory and inhibitory, in neurogenesis and central nervous system development including its control of neuronal cell proliferation and migration, synaptogenesis, dendrite formation and branching, and new neuronal cell integration in the adult brain. There has been remarkable progress in understanding the epigenetic regulations of GABAergic genes and their aberrant expressions in various neurological disorders such as autism spectrum disorder, Rett's syndrome, schizophrenia and PWS. The roles of histone modifications, chromatin looping and gene methylation have been implicated in altered regulations of key genes in the GABAergic pathway. Taken together, they affect the functioning of GABAergic neurotransmission and disrupt various events in brain development. Here, we focus on the role of GABAergic neurotransmission in brain development and on how various genetic and epigenetic events regulate the GABAergic genes in pre- and postnatal brain. We also discuss how these regulatory mechanisms contribute to the pathogenesis of neurological disorders and, therefore, can be used in the development of potential epigenetic therapy for these diseases.
The authors' abstract, as published at the source. Medical Epigenetics, 2016 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience