Journal of the American Heart Association· 2026Q1
Hastalarin Hastanede Yatan Hastalarinda Vücut Kitle İndeksinin Venöz Tromboembolizm Oluşumu ve Mortalitesiyle Paradoksal İlişkisi: Ulusal Hastane Tabanlı Bir Kohort Analizi
Paradoxical Association of Body Mass Index With Occurrence and Mortality of Venous Thromboembolism in Hospitalized Patients: A National Hospital‐Based Cohort Analysis
- 0atıf
- Q1SCImago
- 2026yıl
Kısa özet
Fazla kilolu ve obez hastanede yatan hastalar (VKİ ≥24.0 kg/m²) normal kilolu bireylere kıyasla %18-22 daha düşük venöz tromboembolizm (VTE) geliştirme riski taşıyordu; bu koruyucu etki yaşlı, kadın ve cerrahi hastalarda daha belirgindi.
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Ana noktalar
- Fazla kilolu (VKİ 24.0-27.9) ve obez (VKİ ≥28.0) hastanede yatan hastalarda, normal kilolu (VKİ 18.5-23.9) hastalara kıyasla VTE oluşumu riski sırasıyla %18 ve %22 daha düşüktü.
- Fazla kilolu/obezitenin VTE oluşumu üzerindeki koruyucu etkisi, 65 yaş üstü, kadın ve cerrahi hastalarda daha belirgindi.
- Obezite, iç hastalıkları hastalarında VTE oluşumu için daha yüksek riskle ilişkiliydi (OR, 1.11).
- Obezite, VTE sonrası mortalite riskinde cerrahi hastalarda paradoksal olarak daha düşük bir ilişkiyle ilişkilendirildi (OR, 0.37).
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
Background The association between body mass index (BMI) and venous thromboembolism (VTE) occurrence and mortality is controversial. This study aimed to investigate the association of BMI with VTE occurrence and mortality and explore the consistency across age, sex, and medical specialty. Methods This study included 3 199 526 inpatients at potential risk for VTE from a nationwide hospital‐based cohort. Participants were categorized as lean weight (BMI <18.5 kg/m 2 ), normal weight (18.5 ≤BMI<24.0 kg/m 2 ), overweight (24.0 ≤BMI <28.0 kg/m 2 ), and obesity (BMI ≥28.0 kg/m 2 ). Odds ratios (ORs) were calculated by logistic regression models. Results In all participants, 59 002 (1.8%) developed VTE during hospitalization. After adjusting for the confounding factors, compared with normal weight, the risk of VTE occurrence reduced by 18% (odds ratio [OR], 0.82 [95% CI, 0.80–0.83]) in participants with overweight and 22% (OR, 0.78,[95% CI, 0.75–0.81]) in participants with obesity. The protective association of overweight/obesity was more pronounced in age ≥65 years, female patients, and surgery participants ( P for interaction <0.05), whereas in internal medical participants, obesity was associated with a higher risk of VTE occurrence (OR, 1.11 [95% CI, 1.01–1.21]). A total of 636 (1.1%) patients with VTE died before discharge. No significant association was observed between overweight/obesity and post‐VTE mortality. However, in the surgical subgroup, obesity was associated with a lower risk of post‐VTE mortality (OR, 0.37 [95% CI, 0.17–0.80], P for interaction <0.05). Conclusion An inverse association between BMI and VTE occurrence was observed among at‐risk inpatients, most pronounced in older, female, and surgical subgroups. Notably, obesity remained a risk factor in medical patients, whereas among surgical patients who developed VTE, it was paradoxically associated with lower mortality.
Yazarların özeti; kaynağından alınmıştır. Journal of the American Heart Association, 2026 · DOI ↗
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