Neurology· 2026Q1
Associations of Antibodies Against Several Infections With Alzheimer Disease Neuropathology
- 1citations
- Q1SCImago
- 2026year
Short summary
Antibodies against common infections like herpes simplex virus 1 (HSV1), cytomegalovirus (CMV), and varicella zoster virus (VZV) are associated with increased Alzheimer's disease (AD) neuropathology, including amyloid plaques and neurofibrillary tangles.
AI-generated from the title and abstract; the full text is not read.
Key points
- Antibodies to HSV1, CMV, and VZV are associated with increased AD neuropathology.
- Higher antibody levels correlate with greater amyloid plaque and neurofibrillary tangle burden.
- Associations persisted after controlling for APOE ε4 carriage and education.
- The study used serologic measures of infection and post-mortem brain tissue analysis.
AI-generated from the title and abstract; the full text is not read.
Abstract
BACKGROUND AND OBJECTIVES: Associations of common infections with Alzheimer disease (AD) risk have been reported. A hypothesized mechanism for these is cerebral β-amyloid (Aβ) aggregation as a defense to infection. We studied whether serologic measures of several infections in the UK population are associated with measures of AD neuropathology. METHODS: ε4 carriage, education, and sex, and for interactions between herpes simplex virus 1 exposure with cytomegalovirus (CMV) and varicella zoster virus (VZV) exposure. RESULTS: ). DISCUSSION: ε4 carriage and education in relation to AD neuropathology warrants further study.
The authors' abstract, as published at the source. Neurology, 2026 · DOI ↗
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Field: Physiology
PhysiologyMedicine