Key papers in Physiology
Pofolia’s corpus holds 50 papers from the Physiology subfield (2012–2026). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
Cellular Physiology and Biochemistry · 2013 · Q3 · FWCI 460.23 · 47,290 citations · Open access
Four days of nose-only cigarette smoke exposure in mice significantly increased oxidative stress and disrupted mitochondrial function across liver, kidney, heart, and lung tissues, with lung and heart being particularly affected.
World Medical Association Declaration of Helsinki
JAMA · 2013 · Q1 · SJR 5.00 · FWCI 212.74 · 29,734 citations
The World Medical Association (WMA) has established the Declaration of Helsinki, a foundational document outlining ethical principles for medical research involving human subjects, including identifiable human material and data.
Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) · 2024 · FWCI 529.79 · 24,011 citations · Open access
Two previously undiscovered Later Stone Age archaeological sites dating to the Final Pleistocene have been identified in the Falémé Valley of eastern Senegal.
Sarcopenia: revised European consensus on definition and diagnosis
Age and Ageing · 2018 · Q1 · SJR 2.00 · FWCI 479.95 · 14,163 citations · Open access
The European Working Group on Sarcopenia in Older People (EWGSOP2) has updated the definition of sarcopenia, emphasizing low muscle strength as the primary characteristic, confirmed by low muscle quantity/quality, and indicating severe sarcopenia by poor physical performance.
Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
Scientific Reports · 2016 · Q1 · FWCI 423.03 · 13,291 citations · Open access
Krabbe disease causes severe damage to nerve terminals and neuromuscular junctions in mice by postnatal day 30, with peripheral nerve damage detectable even earlier at day 15, independent of demyelination.
World Health Organization 2020 guidelines on physical activity and sedentary behaviour
British Journal of Sports Medicine · 2020 · Q1 · SJR 4.00 · FWCI 525.87 · 11,193 citations · Open access
New WHO guidelines recommend 150-300 minutes of moderate or 75-150 minutes of vigorous aerobic activity weekly for adults, and 60 minutes daily for children/adolescents, alongside muscle-strengthening and reduced sedentary behavior.
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
Neurodegenerative Diseases · 2012 · Q3 · FWCI 262.79 · 10,400 citations
Chronic exposure to amyloid-beta (Aβ) oligomers, even for as short as 10 days, significantly increases tau phosphorylation and activates GSK3 in a mouse model of tauopathy, suggesting long-lasting effects on neurodegeneration.
‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management
Obesity Facts · 2013 · Q1 · SJR 1.00 · FWCI 440.47 · 9,509 citations · Open access
Behavioral interventions for physical activity are often ineffective, explaining only 30% or less of behavior variability, and rarely measure or systematically change the mediating psychological variables.
Hallmarks of Cancer: New Dimensions
Cancer Discovery · 2022 · Q1 · SJR 7.00 · FWCI 906.76 · 9,260 citations · Open access
This perspective proposes refining the "hallmarks of cancer" framework by adding phenotypic plasticity and disrupted differentiation as a distinct hallmark, and nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics.
The amyloid hypothesis of Alzheimer's disease at 25 years
EMBO Molecular Medicine · 2016 · Q1 · SJR 3.00 · FWCI 282.26 · 6,166 citations · Open access
Twenty-five years after its proposal, the amyloid hypothesis remains the most validated therapeutic target for Alzheimer's disease, with new evidence showing Aβ dyshomeostasis as an early, initiating factor.
Lecanemab in Early Alzheimer’s Disease
New England Journal of Medicine · 2022 · Q1 · SJR 18.00 · FWCI 494.47 · 5,328 citations · Open access
The drug lecanemab, a monoclonal antibody targeting amyloid-beta protofibrils, demonstrated a modest slowing of cognitive and functional decline by 0.45 points on the CDR-SB scale over 18 months in early Alzheimer's patients compared to placebo.
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
Journal of Lipid Research · 2013 · Q1 · SJR 1.00 · FWCI 43.68 · 4,952 citations · Open access
Short-chain fatty acids (SCFAs), produced by gut bacteria fermenting dietary fiber, significantly influence mammalian energy metabolism through complex interactions with diet and host physiology.
Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1·9 million participants
The Lancet Global Health · 2018 · Q1 · SJR 5.00 · FWCI 201.90 · 4,924 citations · Open access
Globally, 27.5% of adults were insufficiently active in 2016, with women being significantly more affected than men, and this rate remained largely stable from 2001 to 2016.
Increased Prevalence of Sleep-Disordered Breathing in Adults
American Journal of Epidemiology · 2013 · Q1 · SJR 1.00 · FWCI 138.01 · 4,608 citations · Open access
Moderate to severe sleep-disordered breathing prevalence has significantly increased in US adults over the past two decades, with relative increases ranging from 14% to 55% across different age and sex subgroups.
Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis
The Lancet Respiratory Medicine · 2019 · Q1 · SJR 7.00 · FWCI 152.11 · 4,096 citations · Open access
An estimated 936 million adults aged 30-69 globally have mild to severe obstructive sleep apnoea (OSA), with 425 million having moderate to severe OSA, based on a novel literature analysis and standardization algorithm.
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
European Respiratory Journal · 2013 · Q1 · SJR 5.00 · FWCI 80.71 · 3,946 citations · Open access
New guidelines define severe asthma as uncontrolled asthma despite high-dose controller therapy, including systemic corticosteroids, and provide recommendations for its evaluation and treatment.
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
The Journals of Gerontology Series A · 2014 · Q1 · SJR 1.00 · FWCI 84.37 · 3,841 citations
Aging is marked by chronic, low-grade inflammation, termed "inflammaging," a significant risk factor for age-related diseases and mortality, though its precise causes and causal role are still unclear.
Sedentary Behavior Research Network (SBRN) – Terminology Consensus Project process and outcome
International Journal of Behavioral Nutrition and Physical Activity · 2017 · Q1 · SJR 2.00 · FWCI 155.58 · 3,797 citations · Open access
A consensus project by the Sedentary Behavior Research Network (SBRN) has established standardized definitions for key terms related to sedentary behavior, aiming to unify research and practice.
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases
Scandinavian Journal of Medicine and Science in Sports · 2015 · Q1 · SJR 1.00 · FWCI 80.48 · 3,512 citations
This review synthesizes evidence for using exercise as therapy across 26 chronic diseases, offering guidance on optimal exercise types and dosages for treatment.
The neuropathological diagnosis of Alzheimer’s disease
Molecular Neurodegeneration · 2019 · Q1 · SJR 6.00 · FWCI 124.83 · 3,357 citations · Open access
Alzheimer's disease diagnosis relies on identifying amyloid plaques and neurofibrillary tangles, but it's increasingly recognized as a complex mixed proteinopathy.
Recently added
Onderzoek naar de rol van tau-aggregaten in neurodegeneratie
Lirias (KU Leuven) · 2026
This PhD project investigates the seeding capacity and toxicity of tau aggregates, aiming to develop novel monoclonal antibodies to neutralize tau's harmful effects in neurodegenerative diseases like Alzheimer's.
Experimental and Therapeutic Medicine
Experimental and Therapeutic Medicine · 2026 · 1,740 citations
The β2-adrenergic agonist formoterol significantly reversed muscle wasting and improved physical performance in cachectic rats bearing Yoshida AH-130 ascites hepatoma tumors.
Physical Activity and Exercise Intensity Terminology: A Joint American College of Sports Medicine (ACSM) Expert Statement and Exercise and Sport Science Australia (ESSA) Consensus Statement
Medicine & Science in Sports & Exercise · 2025 · Q1 · SJR 1.00 · FWCI 25.65 · 39 citations
A joint ACSM/ESSA consensus statement proposes standardized terminology for physical activity and exercise intensity, defining five levels: very low, low, moderate, high, and very high, each with a corresponding perception of effort descriptor (very easy to very hard).
Simulated microgravity accurately models long-duration spaceflight effects on bone and skeletal muscle in skeletally immature mice
Bone Reports · 2025 · Q2 · FWCI 1.33 · 2 citations
Simulated microgravity via hindlimb unloading (HLU) effectively models long-duration spaceflight (SF) effects on bone and skeletal muscle in young mice, showing similar, though slightly less severe, bone and muscle loss compared to actual SF.
Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) · 2024 · FWCI 529.79 · 24,011 citations · Open access
Two previously undiscovered Later Stone Age archaeological sites dating to the Final Pleistocene have been identified in the Falémé Valley of eastern Senegal.
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