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EMBO Molecular Medicine· 2016Q1· Review

The amyloid hypothesis of Alzheimer's disease at 25 years

Dennis J. Selkoe, John Hardy

Short summary

Twenty-five years after its proposal, the amyloid hypothesis remains the most validated therapeutic target for Alzheimer's disease, with new evidence showing Aβ dyshomeostasis as an early, initiating factor.

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Field: Physiology

PhysiologyMedicine