The Journals of Gerontology Series A· 2014Q1· Review
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
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- Q1SCImago
- 2014year
Short summary
Aging is marked by chronic, low-grade inflammation, termed "inflammaging," a significant risk factor for age-related diseases and mortality, though its precise causes and causal role are still unclear.
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Key points
- Aging is associated with chronic, low-grade inflammation called "inflammaging."
- Inflammaging is a significant risk factor for age-related diseases and mortality.
- The precise causes and causal role of inflammaging in adverse health outcomes are not yet understood.
- Understanding inflammaging pathways is key to developing potential treatments for the elderly.
AI-generated from the title and abstract; the full text is not read.
Abstract
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as "inflammaging." Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, the precise etiology of inflammaging and its potential causal role in contributing to adverse health outcomes remain largely unknown. The identification of pathways that control age-related inflammation across multiple systems is therefore important in order to understand whether treatments that modulate inflammaging may be beneficial in old people. The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging. This article reports the main outcomes of this session.
The authors' abstract, as published at the source. The Journals of Gerontology Series A, 2014 · DOI ↗
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Field: Physiology
PhysiologyMedicine