Advanced Science· 2026Q1
Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H 2 S Gasotransmission for Multifactorial Diabetic Wound Therapy
- 1citations
- Q1SCImago
- 2026year
Short summary
A neutrophil-membrane-coated, quercetin-loaded nanoparticle hydrogel (QN-S-HG) with pH-triggered hydrogen sulfide (H2S) release accelerates diabetic wound healing by targeting inflammation, reducing oxidative stress, killing bacteria, and promoting blood vessel growth.
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Key points
- Developed a biomimetic nanocomposite hydrogel (QN-S-HG) for diabetic wound healing.
- Neutrophil-mimetic nanoparticles deliver quercetin, providing anti-inflammatory, antioxidant, and antibacterial actions.
- Acid-triggered H2S release from the hydrogel scaffold promotes angiogenesis.
- The hydrogel exhibits injectability, self-healing, and tissue adhesion.
- QN-S-HG accelerated wound closure and promoted tissue regeneration in diabetic rats.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Diabetic wounds remain a persistent clinical challenge due to the intertwined pathologies of chronic inflammation, oxidative stress, bacterial colonization, and impaired neovascularization. Conventional hydrogel dressings, however, typically lack both the spatiotemporal precision and synergistic multifunctionality that are required to counteract the complex pathological drivers of diabetic wound chronicity. Here, we present a biomimetic nanocomposite hydrogel (QN‐S‐HG) that integrates neutrophil‐membrane‐coated quercetin‐loaded nanoparticles with a pH‐responsive hydrogen sulfide (H 2 S) releasing hyaluronic acid network. The neutrophil‐mimetic nanoparticles achieve dual‐targeted delivery to inflammatory cells and bacteria, simultaneously exerting anti‐inflammatory, antioxidant, and broad‐spectrum antibacterial effects. Concurrently, the H 2 S donor S‐propargylcysteine (SPRC) is covalently conjugated via dynamic Schiff base bonds to the hydrogel scaffold, enabling acid‐triggered release in the pathological wound milieu to stimulate angiogenesis. Remarkably, the crosslinker‐free and hydrogen‐bond‐mediated hyaluronic acid network endows the hydrogel with injectability, self‐healing, and tissue‐adhesive properties, ensuring conformal coverage and sustained local bioactivity. In a diabetic rat full‐thickness wound model, QN‐S‐HG markedly accelerates closure, promotes macrophage repolarization, enhances neovascularization, and facilitates orderly collagen remodeling with hair follicle regeneration. By orchestrating targeted pharmacotherapy, microenvironment‐triggered gaseous signaling, and adaptive material mechanics, this platform addresses the multifaceted pathophysiology of diabetic wounds and offers a clinically translatable paradigm for advanced regenerative wound care.
The authors' abstract, as published at the source. Advanced Science, 2026 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine