Open Biology· 2020Q1· Review
Wound healing: cellular mechanisms and pathological outcomes
- 1,731citations
- Q1SCImago
- 2020year
Short summary
This review synthesizes the cellular events crucial for efficient tissue repair and explores how their derangement, particularly in conditions like diabetes and aging, leads to chronic, non-healing wounds.
AI-generated from the title and abstract; the full text is not read.
Key points
- Wound healing relies on tightly coordinated cellular events for efficient tissue repair.
- Derangements in cellular behaviors, common in diabetes and aging, impair healing.
- Chronic, non-healing wounds represent a significant socioeconomic burden.
- Improved understanding of wound pathology is needed for developing new therapies.
AI-generated from the title and abstract; the full text is not read.
Abstract
Wound healing is a complex, dynamic process supported by a myriad of cellular events that must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound-linked cellular behaviours, as occurs with diabetes and ageing, can lead to healing impairment and the formation of chronic, non-healing wounds. These wounds are a significant socioeconomic burden due to their high prevalence and recurrence. Thus, there is an urgent requirement for the improved biological and clinical understanding of the mechanisms that underpin wound repair. Here, we review the cellular basis of tissue repair and discuss how current and emerging understanding of wound pathology could inform future development of efficacious wound therapies.
The authors' abstract, as published at the source. Open Biology, 2020 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine