Science Translational Medicine· 2014Q1· Review
Wound repair and regeneration: Mechanisms, signaling, and translation
- 3,449citations
- Q1SCImago
- 2014year
Short summary
Current therapies for poor wound healing are limited due to a poor understanding of the underlying cellular and molecular mechanisms. This review highlights emerging concepts in tissue repair and regeneration to guide clinical translation.
AI-generated from the title and abstract; the full text is not read.
Key points
- Poor wound healing affects millions annually due to dysregulated repair processes.
- Underlying clinical conditions like diabetes and aging are frequently linked to healing pathologies.
- Understanding basic repair biology is crucial for developing new clinical strategies.
- The review focuses on emerging concepts for translating knowledge into clinical approaches.
AI-generated from the title and abstract; the full text is not read.
Abstract
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.
The authors' abstract, as published at the source. Science Translational Medicine, 2014 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine