Allergy and Asthma Proceedings· 2026Q2
Treatment-refractory chronic urticaria with neutrophilia and elevated inflammatory markers
- 1citations
- Q2SCImago
- 2026year
Short summary
A case report highlights the need to consider chronic urticaria mimics, such as autoinflammatory syndromes, in patients with persistent symptoms and elevated inflammatory markers despite standard treatments.
AI-generated from the title and abstract; the full text is not read.
Key points
- Presents a case of chronic spontaneous urticaria resistant to high-dose antihistamines, anti-IgE, and cyclosporine.
- The patient exhibited persistent neutrophilia and elevated inflammatory markers.
- Differential diagnosis included urticarial vasculitis, autoimmune disease, hematologic disease, and autoinflammatory syndromes.
- Skin biopsy and expanded laboratory testing were crucial for evaluation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Chronic spontaneous urticaria is commonly responsive to high-dose antihistamines, anti-IgE therapy, and cyclosporine; however, a subset of patients have persistent symptoms despite guideline-directed treatment. We present a case of long-standing, treatment-refractory urticaria in a 38-year-old man with persistent neutrophilia and elevated inflammatory markers. The clinical presentation prompted consideration of chronic spontaneous urticaria mimics, including urticarial vasculitis, autoimmune disease, hematologic disease, and autoinflammatory syndromes. Further evaluation included skin biopsy, expanded laboratory testing, and additional targeted investigations. This case highlights the importance of broadening the differential diagnosis in patients with chronic urticaria that is refractory to standard therapy, particularly when systemic inflammatory features are present.
The authors' abstract, as published at the source. Allergy and Asthma Proceedings, 2026 · DOI ↗
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Field: Rheumatology
RheumatologyMedicine