Drug Design Development and Therapy· 2026Q1· Review
Apigenin: Antihypertensive Effects and Underlying Mechanisms — A Comprehensive Review
- 0citations
- Q1SCImago
- 2026year
Short summary
Apigenin, a dietary flavone, demonstrates antihypertensive effects via four core pathways, but its poor solubility hinders oral bioavailability and clinical translation.
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Key points
- Apigenin exhibits multi-target hypotensive effects through four identified core antihypertensive pathways.
- Poor water solubility is a major limitation for apigenin's oral bioavailability and industrial use.
- Current human evidence for apigenin's antihypertensive efficacy is limited, relying on crude extracts rather than purified compound.
- Strategies like food-grade nanoformulation and standardized clinical trials are proposed to overcome translational bottlenecks.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract: Apigenin, a ubiquitous dietary flavone from vegetables, fruits and herbal teas, exhibits multi-target hypotensive effects, yet its poor water solubility limits oral bioavailability and industrial translation. Previous reviews only summarized its general bioactivities and anti-atherosclerotic effects, without comprehensively analyzing its antihypertensive mechanisms. Most evidence derives from preclinical studies; human trials merely use crude celery seed extracts instead of purified apigenin, lacking reliable clinical proof for its antihypertensive efficacy. This review summarizes apigenin’s sources, chemical properties, safety and solubility-enhanced delivery systems to support functional food exploitation. We elaborate four core antihypertensive pathways, and also point out translational bottlenecks and propose strategies including food-grade nanoformulation and standardized clinical trials. This work links preclinical mechanisms to food industry application, providing theoretical evidence for developing apigenin-enriched functional foods for hypertension adjuvant intervention. Keywords: apigenin, hypertension, antioxidant, anti-inflammation, blood pressure, flavone
The authors' abstract, as published at the source. Drug Design Development and Therapy, 2026 · DOI ↗
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Field: Pharmacology (Medicine)
PharmacologyMedicine