Biomacromolecules· 2026Q1
Sprayable Hydrogel-Mediated Ultrasound Transdermal Drug Delivery for Gouty Arthritis Treatment
- 0citations
- Q1SCImago
- 2026year
Short summary
A novel sprayable, ultrasound-responsive hydrogel delivers colchicine transdermally for gouty arthritis, acting as both a coupling agent and a sustained-release depot.
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Key points
- Developed a sprayable hydrogel that acts as both an ultrasound coupling agent and a sustained-release drug depot.
- The hydrogel encapsulates colchicine, with ultrasound enhancing transdermal penetration and accelerating drug release.
- In vivo studies showed significant reduction in joint swelling and inflammatory cytokines in gouty arthritis models.
- The platform preserved bone architecture and improved motor function, offering a noninvasive therapeutic strategy.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Gouty arthritis (GA) is an acute inflammatory joint disease characterized by severe pain and recurrent attacks. Current local therapies are limited by the invasiveness of intra-articular injection or the poor efficiency of conventional transdermal drug delivery. Although ultrasound-mediated transdermal delivery enhances skin permeability noninvasively, conventional coupling agents require removal after treatment and cannot sustain local drug release. Herein, we report an ultrasound-assisted sprayable hydrogel that replaces conventional coupling agents and enables sustained local drug delivery. Rapid ionic crosslinking of sodium alginate (SA) with Ca2+ forms a colchicine-loaded depot. Ultrasound enhances transdermal penetration and accelerates drug release, while the residual hydrogel sustains release after treatment. In vivo, the platform alleviates joint swelling, suppresses inflammatory cytokines, preserves bone architecture, and improves motor function in gouty arthritis. This noninvasive platform offers a potential therapeutic strategy for gouty arthritis and other inflammatory musculoskeletal disorders.
The authors' abstract, as published at the source. Biomacromolecules, 2026 · DOI ↗
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Field: Pharmaceutical Science
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics