Pharmaceuticals· 2025Q1· Review
Mesoporous Silica Nanoparticles as Drug Delivery Systems
- 36citations
- Q1SCImago
- 2025year
Short summary
Mesoporous silica nanoparticles (MSNs) stabilize amorphous drugs, improving solubility and protecting against degradation, which enhances bioavailability and enables targeted delivery.
AI-generated from the title and abstract; the full text is not read.
Key points
- MSNs stabilize APIs in an amorphous state, enhancing aqueous solubility.
- Encapsulation protects drugs from enzymatic or chemical degradation.
- Particle size and surface functionalization enable targeted delivery.
- Targeted delivery improves therapeutic outcomes and minimizes side effects.
AI-generated from the title and abstract; the full text is not read.
Abstract
Mesoporous silica nanocarriers (MSNs) have emerged as significant candidates in the pharmaceutical industry for drug delivery systems, suitable for a wide variety of drugs. Absorbing the active pharmaceutical ingredients (APIs) into the pores can be beneficial in several ways. The narrow pores may stabilize the APIs in an amorphous state, thereby improving its aqueous solubility and providing protection for the encapsulated drug against various factors in the human body, including enzymatic or chemical degradation, which enhances the bioavailability of the product. Beside the overview of their main characteristics, the present review focuses on the recent findings on MSNs form therapeutic and drug formulation perspective, including functionalization possibilities, as the size and surface of the particles influence the interactions with the cell membrane; therefore, the epithelial permeability of and release rate from the carrier, and may offer even targeted delivery in an organ-, tissue- or cell-specific manner, improving the therapy, also avoiding drug-related side effects.
The authors' abstract, as published at the source. Pharmaceuticals, 2025 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Pharmaceutical Science
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics