International Journal of Nanomedicine· 2025Q1· Review
Bridging the Gap: The Role of Advanced Formulation Strategies in the Clinical Translation of Nanoparticle-Based Drug Delivery Systems
- 105citations
- Q1SCImago
- 2025year
Short summary
Advanced formulation strategies, beyond nanoparticle design alone, are critical for translating laboratory-based nanoparticle drug delivery systems into clinical applications, addressing challenges like stability and bioavailability for specific routes of administration.
AI-generated from the title and abstract; the full text is not read.
Key points
- A significant "translational gap" exists in nanomedicine, with most lab-based nanoparticles failing to reach clinical application.
- Advanced formulation strategies, using secondary delivery systems, are crucial for bridging this gap.
- Different formulation platforms (injectables, hydrogels, microspheres, dry powders, implants) address specific clinical challenges for various administration routes.
- Successful translation requires integrating nanoparticle design with formulation strategies to ensure stability and bioavailability.
AI-generated from the title and abstract; the full text is not read.
Abstract
Although nanoparticles (NPs) show tremendous potential in the laboratory, most of them fail to reach clinical applications, highlighting a significant "translational gap" in nanomedicine. This gap is often due to a lack of focus on advanced formulation strategies required to transform NPs into functional drug products. Therefore, this review systematically addresses the crucial role of secondary delivery systems in bridging this gap. We analyze and compare various advanced formulation platforms, such as sterile injectables for the intravenous route, hydrogels for topical delivery, microspheres for the oral route, dry powder formulations for inhalation, and polymer implants for controlled release, and discuss how each system addresses specific clinical challenges related to route of administration, stability, and bioavailability. We conclude that shifting the focus from nanoparticle design alone to integrated formulation strategies is a fundamental step towards accelerating the translation of nanomedicines from the laboratory to the patient.
The authors' abstract, as published at the source. International Journal of Nanomedicine, 2025 · DOI ↗
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Field: Pharmaceutical Science
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics