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Radiology· 2026Q1

Comparing Glymphatic Function Measures: Diffusion Tensor Image Analysis Along Perivascular Spaces (DTI-ALPS) versus Intrathecal Contrast-Enhanced MRI

Ingrid Mossige, Lars Magnus Valnes, T. Storås, Kyrre E. Emblem et al.

Short summary

Intrathecal contrast-enhanced MRI (gMRI) shows limited association with Diffusion Tensor Image Analysis Along Perivascular Spaces (DTI-ALPS) in measuring glymphatic function, suggesting DTI-ALPS may not be a reliable proxy for gMRI-assessed glymphatic function.

AI-generated from the title and abstract; the full text is not read.

Key points

  • Intrathecal contrast-enhanced MRI (gMRI) showed sparse contrast enhancement in ALPS regions across all groups.
  • The association between the ALPS index and gMRI markers of glymphatic function was limited.
  • DTI-ALPS may not be a reliable surrogate for gMRI-assessed glymphatic function.

AI-generated from the title and abstract; the full text is not read.

Abstract

≥ .55). Conclusion CSF tracer enhancement in the ALPS regions of interest was sparse across groups, and the association between the ALPS index and gMRI markers of glymphatic function was limited. © The Author(s) 2026. Published by the Radiological Society of North America under a CC BY 4.0 license.

The authors' abstract, as published at the source. Radiology, 2026 · DOI ↗

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Field: Cellular and Molecular Neuroscience

Cellular and Molecular NeuroscienceNeuroscience