Archives of Medical Science· 2015Q2· Review
Brain-derived neurotrophic factor and its clinical implications
- 1,340citations
- Q2SCImago
- 2015year
Short summary
Brain-derived neurotrophic factor (BDNF) is crucial for neuronal survival, growth, and plasticity, impacting learning and memory. Its signaling pathways are also involved in regulating glucose metabolism and protecting pancreatic beta cells.
AI-generated from the title and abstract; the full text is not read.
Key points
- BDNF supports neuronal survival, growth, and plasticity, fundamental for learning and memory.
- BDNF signaling involves TrkB receptor activation and downstream cascades like PI3K/Akt, influencing CREB and CBP.
- BDNF regulates glucose and energy metabolism and prevents beta cell exhaustion.
- Reduced BDNF levels are linked to neurodegenerative diseases such as Parkinson's and Alzheimer's.
AI-generated from the title and abstract; the full text is not read.
Abstract
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues. BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival. BDNF and insulin-like growth factor-1 have similar downstream signaling mechanisms incorporating both p-CAMK and MAPK that increase the expression of pro-survival genes. Brain-derived neurotrophic factor regulates glucose and energy metabolism and prevents exhaustion of β cells. Decreased levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. Thus, BDNF may be useful in the prevention and management of several diseases including diabetes mellitus.
The authors' abstract, as published at the source. Archives of Medical Science, 2015 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience