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Organic Letters· 2026Q1

Harnessing Diazo Compounds as Alkoxycarbonyl Methylene Radical Linchpins: Truce–Smiles Rearrangement toward Amido Esters and Isoquinolinedione Scaffolds

Suman Sasmal, Neerathilingam Nalladhambi, Govindasamy Sekar

Short summary

A photochemical Truce–Smiles rearrangement of N-aryl-N-arylsulfonyl acrylamides using diazo compounds as radical precursors yields β,β′-disubstituted amido esters and isoquinolinediones.

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Field: Organic Chemistry

Organic ChemistryChemistry