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Science· 2026Q1

Conformational asymmetry of replicated human chromosomes

Flavia Corsi, Sofia Kolesnikova, Thomas L. Steinacker, Zsuzsanna Takács et al.

Short summary

Replicated human chromosomes exhibit a genome-wide, consistent shift in sister chromatid alignment, biased along the 5′-3′ direction of inherited DNA strands, a phenomenon driven by replication fork asymmetry and maintained by cohesin complexes.

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Molecular BiologyBiochemistry, Genetics and Molecular Biology