Journal of Translational Medicine· 2026Q1· Review
Perioperative non-invasive neuromodulation for delirium and cognitive recovery: from preclinical evidence to clinical translation
- 0citations
- Q1SCImago
- 2026year
Short summary
Non-invasive neuromodulation (NIN) techniques, including tDCS, rTMS, and others, show promise in reducing perioperative neurocognitive disorders (PND) and improving cognitive recovery in surgical patients.
AI-generated from the title and abstract; the full text is not read.
Key points
- Non-invasive neuromodulation (NIN) encompasses techniques like tDCS, rTMS, tACS, tUS, TIS, taVNS, tPBM, and GENUS.
- NIN shows potential in reducing delirium and improving cognitive recovery in surgical patients.
- Evidence spans from preclinical studies to clinical translational trials.
- Further research is needed to optimize device parameters, stimulation protocols, and understand effects on brain network connectivity.
AI-generated from the title and abstract; the full text is not read.
Abstract
Perioperative neurocognitive disorders (PND) are a challenge for patients to accelerate postoperative recovery, and exploring more effective interventions can help reduce long-term cognitive dysfunction. Non-invasive neuromodulation (NIN) has shown potential in improving postoperative cognitive function and reducing delirium. This review aims to summarize the impact of NIN technology on the incidence of PND, including preclinical studies and clinical translational trials. Neuromodulation techniques include transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), Theta burst stimulation (TBS), transcranial alternating current stimulation (tACS), transcranial ultrasound stimulation (tUS), temporal interference stimulation (TIS), transcutaneous auricular vagus nerve stimulation (taVNS), transcranial photobiomodulation (tPBM), and 40-Hz Gamma entrainment using sensory stimuli (GENUS). Preliminary evidence suggests that NIN technology may have benefits in improving delirium and cognitive recovery in surgical patients. Further research may need to pay more attention to the technical parameters of the device, stimulation protocols, and the global effects on brain network connectivity. Strict clinical trials, adoption of multimodal brain network monitoring, and optimization of technical solutions are still needed in the future.
The authors' abstract, as published at the source. Journal of Translational Medicine, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Critical Care and Intensive Care Medicine
Critical Care and Intensive Care MedicineMedicine