BMC Biology· 2026Q1

The D380 residue in MCO1 regulates neural iron homeostasis and fitness in Drosophila

Xuejiao Chang, Yudie Ma, Shanling Jiang, Huizhong Gao et al.

0citations
Q1SCImago
2026year

Short summary

Disrupting the D380 residue in Drosophila MCO1 specifically blocks its ferroxidase activity, leading to ferrous iron and ROS accumulation in the aging brain, impaired development, reduced locomotion, and shortened lifespan.

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Field: Neurology (Neuroscience)

NeurologyNeuroscience