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Neurology· 2026Q1

Carotid Artery Stenting Is Now an Evidence-Based Adjunct to Intensive Medical Therapy for Stroke Prevention

James F. Meschia

Short summary

Carotid artery stenting (CAS) combined with intensive medical management (IMM) significantly reduces stroke risk in patients with high-grade asymptomatic carotid stenosis compared to IMM alone, according to the CREST-2 trial.

AI-generated from the title and abstract; the full text is not read.

Key points

  • CREST-2 trial shows CAS + IMM reduces stroke risk vs. IMM alone in high-grade asymptomatic carotid stenosis.
  • Careful patient selection and operator skill are critical for successful CAS.
  • CAS is validated as an important adjunct to IMM for stroke prevention.
  • Shared decision-making is vital when considering CAS for asymptomatic stenosis.

AI-generated from the title and abstract; the full text is not read.

Abstract

The CREST-2 trial demonstrated that carotid artery stenting combined with intensive medical management (IMM) significantly reduces stroke risk in patients with high-grade asymptomatic carotid stenosis compared with IMM alone. Careful patient selection and operator skill are critical factors for procedural success and can provide real-world validation of stenting as an important adjunct to IMM for stroke prevention. Continued advances in medical management and stenting are expected. It remains vital to engage in shared decision-making when considering moving forward with stenting of asymptomatic carotid stenosis.

The authors' abstract, as published at the source. Neurology, 2026 · DOI ↗

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Field: Pulmonary and Respiratory Medicine

Pulmonary and Respiratory MedicineMedicine