Chemical Reviews· 2018Q1· Review
Molecularly Imprinted Polymers
- 1,587citations
- Q1SCImago
- 2018year
Short summary
Molecularly imprinted polymers (MIPs) are synthetic receptors analogous to natural antibodies, designed to selectively bind target molecules. This review focuses on their application as sensors, where MIPs are coupled with reporting systems (electrical, optical, etc.) to detect analytes.
AI-generated from the title and abstract; the full text is not read.
Key points
- MIPs act as synthetic antibodies for targeted molecule recognition.
- Sensors integrate MIPs with electrical, electrochemical, optical, or gravimetric reporting systems.
- Applications include detecting toxic chemicals, food toxins, drugs, explosives, and pathogens.
- The review covers MIP production, reporting techniques, and sensor applications, with a focus on solution targets.
AI-generated from the title and abstract; the full text is not read.
Abstract
Molecularly imprinted polymers are synthetic receptors for a targeted molecule. As such, they are analogues of the natural antibody-antigen systems. In this review, after a recounting of the early history of the general field, we specifically focus on the application of these polymers as sensors. In these applications, the polymers are paired with a reporting system, which may be electrical, electrochemical, optical, or gravimetric. The presence of the targeted molecule effects a change in the reporting agent, and a calibrated quantity of the target is recorded. In this review, we describe the imprinted polymer production processes, the techniques used for reporting, and the applications of the reported sensors. A brief survey of recent applications to gas-phase sensing is included, but the focus is primarily on the development of sensors for targets in solution. Included among the applications are those designed to detect toxic chemicals, toxins in foods, drugs, explosives, and pathogens. The application of computational chemistry to the development of new imprinted polymers is included as is a brief assessment of future developments.
The authors' abstract, as published at the source. Chemical Reviews, 2018 · DOI ↗
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Field: Analytical Chemistry
Analytical ChemistryChemistry