Journal of Medicinal Chemistry· 2014Q1· Review

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

Edon Vitaku, David T. Smith, Jón T. Njardarson

Short summary

Nitrogen heterocycles are crucial in drug design, with 59% of U.S. FDA-approved small-molecule drugs containing them.

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Organic ChemistryChemistry