Angewandte Chemie International Edition· 2012Q1· Review
Beyond Directing Groups: Transition‐Metal‐Catalyzed CH Activation of Simple Arenes
- 1,630citations
- Q1SCImago
- 2012year
Short summary
This review highlights recent advances in non-chelate-assisted C-H activation, enabling the direct functionalization of simple arenes without relying on directing groups.
AI-generated from the title and abstract; the full text is not read.
Key points
- Established C-H activation relies on directing groups for reactivity and regioselectivity.
- A growing interest exists in directly functionalizing simple arenes without directing groups.
- New strategies are required to achieve reactivity and control selectivity in direct C-H activation.
- This review covers recent advances in non-chelate-assisted C-H activation.
AI-generated from the title and abstract; the full text is not read.
Abstract
The use of coordinating moieties as directing groups for the functionalization of aromatic C-H bonds has become an established tool to enhance reactivity and induce regioselectivity. Nevertheless, with regard to the synthetic applicability of C-H activation, there is a growing interest in transformations in which the directing group can be fully abandoned, thus allowing the direct functionalization of simple benzene derivatives. However, this approach requires the disclosure of new strategies to achieve reactivity and to control selectivity. In this review, recent advances in the emerging field of non-chelate-assisted C-H activation are discussed, highlighting some of the most intriguing and inspiring examples of induction of reactivity and selectivity.
The authors' abstract, as published at the source. Angewandte Chemie International Edition, 2012 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry