Chemical Reviews· 2017Q1· Review
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
- 2,138citations
- Q1SCImago
- 2017year
Short summary
This review comprehensively highlights recent advances in intra- and intermolecular C-H amination reactions using late transition metal catalysts, categorizing findings by mechanistic scaffolds and reaction types.
AI-generated from the title and abstract; the full text is not read.
Key points
- Transition metal catalysis enables efficient synthesis of C-N bonds from C-H bonds.
- The review focuses on intra- and intermolecular C-H amination reactions.
- Late transition metal catalysts are highlighted for these transformations.
- Advances are categorized by mechanistic scaffolds and reaction types.
- Reactivity and selectivity of novel systems are discussed based on proposed working modes.
AI-generated from the title and abstract; the full text is not read.
Abstract
Catalytic transformation of ubiquitous C-H bonds into valuable C-N bonds offers an efficient synthetic approach to construct N-functionalized molecules. Over the last few decades, transition metal catalysis has been repeatedly proven to be a powerful tool for the direct conversion of cheap hydrocarbons to synthetically versatile amino-containing compounds. This Review comprehensively highlights recent advances in intra- and intermolecular C-H amination reactions utilizing late transition metal-based catalysts. Initial discovery, mechanistic study, and additional applications were categorized on the basis of the mechanistic scaffolds and types of reactions. Reactivity and selectivity of novel systems are discussed in three sections, with each being defined by a proposed working mode.
The authors' abstract, as published at the source. Chemical Reviews, 2017 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry