Chemical Society Reviews· 2013Q1· Review
Mechanochemical organic synthesis
- 1,043citations
- Q1SCImago
- 2013year
Short summary
Mechanical milling (ball milling) is a solvent-free technique now widely used for diverse organic reactions, including metal-mediated, condensation, addition, cascade, and cycloaddition reactions.
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Key points
- Ball milling enables solvent-free organic synthesis, reducing environmental impact.
- The technique is applicable to a wide array of reaction classes, including metal-mediated, condensation, addition, cascade, Diels-Alder, oxidation, and reduction reactions.
- Mechanochemistry is effective for synthesizing complex structures such as calixarenes, rotaxanes, and cage compounds.
- Applications extend to asymmetric synthesis and transformations of biologically active molecules.
AI-generated from the title and abstract; the full text is not read.
Abstract
Recently, mechanical milling using a mixer mill or planetary mill has been fruitfully utilized in organic synthesis under solvent-free conditions. This review article provides a comprehensive overview of various solvent-free mechanochemical organic reactions, including metal-mediated or -catalyzed reactions, condensation reactions, nucleophilic additions, cascade reactions, Diels-Alder reactions, oxidations, reductions, halogenation/aminohalogenation, etc. The ball milling technique has also been applied to the synthesis of calixarenes, rotaxanes and cage compounds, asymmetric synthesis as well as the transformation of biologically active compounds.
The authors' abstract, as published at the source. Chemical Society Reviews, 2013 · DOI ↗
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Field: Physical and Theoretical Chemistry
Physical and Theoretical ChemistryChemistry