Chemical Science· 2018Q1
Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?
- 960citations
- Q1SCImago
- 2018year
Short summary
Mechanochemistry, a solvent-free grinding technique, offers synthetic chemists advantages over traditional solution-based methods, including faster reaction times, altered product selectivity, and access to unique products not achievable in solution.
AI-generated from the title and abstract; the full text is not read.
Key points
- Mechanochemistry utilizes solvent-free grinding for molecular synthesis.
- It can significantly reduce reaction times compared to solution-based methods.
- Mechanochemical reactions often yield different product selectivities.
- Unique reaction products, inaccessible in solution, can be formed via mechanochemistry.
AI-generated from the title and abstract; the full text is not read.
Abstract
Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency. Whilst mechanochemical methods are solvent free and can therefore lead to improved sustainability metrics, it is more likely that the significant differences between reaction outcomes, reaction selectivities and reduced reaction times will make it a technique of interest to synthetic chemists. Herein, we provide an overview of mechanochemistry reaction examples, with 'direct' comparators to solvent based reactions, which collectively seemingly show that solid state grinding can lead to reduced reaction times, different reaction outcomes in product selectivity and in some instances different reaction products, including products not accessible in solution.
The authors' abstract, as published at the source. Chemical Science, 2018 · DOI ↗
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Field: Physical and Theoretical Chemistry
Physical and Theoretical ChemistryChemistry