The Journal of Organic Chemistry· 2017Q2
Altering Product Selectivity by Mechanochemistry
- 717citations
- Q2SCImago
- 2017year
Short summary
Mechanochemical activation via grinding or milling can alter chemical reactivity and selectivity, leading to different product compositions or equilibrium mixtures compared to solution-based reactions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Mechanochemical activation (grinding, shearing, pulling, milling) opens unique opportunities in organic synthesis.
- Mechanochemistry facilitates reactions with insoluble reactants and enables solvent-free procedures.
- Mechanochemical techniques can alter chemical reactivity and selectivity compared to solution-based protocols.
- Solvent-free milling can yield different product compositions or equilibrium mixtures than in solution.
- Mechanochemistry allows trapping and characterization of elusive intermediates.
AI-generated from the title and abstract; the full text is not read.
Abstract
Mechanochemical activation achieved by grinding, shearing, pulling, or milling opens unique opportunities in synthetic organic chemistry. Common features are that mechanochemistry facilitates reactions with insoluble reactants, enables high-yielding solvent-free synthetic procedures, and shortens reaction times, among others. However, mechanochemical techniques can also alter chemical reactivity and selectivity compared to the analogous solution-based protocols. As a consequence, solvent-free milling can lead to different product compositions or equilibration mixtures than in solution. Reactions by milling have also allowed the trapping and characterization of elusive intermediates and materials. In this Perspective we highlight a few selected examples that illustrate the value of mechanochemistry in uncovering interesting chemical reactivity, which is often masked in typical liquid-phase synthesis.
The authors' abstract, as published at the source. The Journal of Organic Chemistry, 2017 · DOI ↗
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Field: Physical and Theoretical Chemistry
Physical and Theoretical ChemistryChemistry