International Journal of Molecular Sciences· 2026Q1
Role of the Gut–Liver–Kidney Axis in Disease Manifestation and Biomarker Alterations
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- Q1SCImago
- 2026year
Short summary
The gut-liver-kidney axis significantly influences disease progression and the accumulation of endogenous and exogenous biomarkers, particularly in chronic disorders and neonatal inborn errors of metabolism.
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Key points
- The gut-liver-kidney axis is a key modulator of disease progression.
- Both host and bacterial enzymes contribute to the metabolism of biomarkers.
- Disease manifestation and biomarker accumulation are influenced by this axis.
- The axis is relevant for chronic disorders and neonatal inborn errors of metabolism.
AI-generated from the title and abstract; the full text is not read.
Abstract
Biomarkers with potential for use in clinical diagnosis have been widely studied using biochemical techniques. In particular, endogenous and exogenous metabolites have been targeted in clinical settings. Both types of metabolites are either unmetabolized, metabolized with human enzymes, or metabolized with host-resident bacterial enzymes. In standard clinical chemistry, a specimen must be collected following overnight fasting to minimize the effect of dietary input and the subsequent host and microbial metabolism. Current technology allows the detection of nanomolar concentrations of exogenously derived biomarkers, and these ultra-high sensitivity assays have increased the use of trace amounts of such biomarkers. This narrative review explores how the gut–liver–kidney axis modulates disease manifestation and biomarker accumulations in chronic disorders and inborn errors of metabolism in neonates.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2026 · DOI ↗
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Field: Clinical Biochemistry
Clinical BiochemistryBiochemistry, Genetics and Molecular Biology