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EBioMedicine· 2026Q1

ERK-dependent hyperexcitability of BLA neurons projecting to dCA3 underlies social dysfunction in a male mouse model of fragile X syndrome

Siyu Wang, Xiaotong Wu, Siyuan Dong, Lu Zheng et al.

Short summary

BLA-dCA3 projecting neurons are hyperactive in male Fmr1 KO mice, and inhibiting this pathway rescues social deficits, while activating it in WT mice impairs social discrimination.

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GeneticsBiochemistry, Genetics and Molecular Biology