Nature Communications· 2026Q1
Hierarchical regulation of oxygen-sensing through coupled transducers in Arabidopsis thaliana
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- 2026year
Short summary
Arabidopsis HYPOXIA TRANSDUCER1 (HYT1) is stabilized by hypoxia via a Cys-2 dependent N-degron, acting as a key transducer in oxygen-sensing and stress tolerance.
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Key points
- HYPOXIA TRANSDUCER1 (HYT1) is a substrate of the PLANT CYSTEINE OXIDASE (PCO) N-degron pathway, stabilized by acute hypoxia.
- HYT1 is an angiosperm-specific tail-anchored domain protein localized to the endoplasmic reticulum and nucleus.
- HYT1 is essential for tolerance to acute hypoxia and other stress responses.
- Expression of HYT1 is directly activated by ERFVII transcription factors, creating a hypoxia-initiated feed-forward loop.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract The sensing of molecular oxygen is an essential component of development and environmental response in both animals and plants. Few substrates of the plant oxygen-sensing PLANT CYSTEINE OXIDASE (PCO) N-degron pathway have been identified. Here we show that HYPOXIA TRANSDUCER1 (HYT1, previously named HYPOXIA-RESPONSIVE UNKNOWN PROTEIN, HUP40), an angiosperm-specific tail anchored-domain protein, is a substrate of this pathway through a Cys-2 dependent N-degron. HYT1 is stabilised in response to acute hypoxia in root tissues and is associated with the endoplasmic reticulum and nucleus. Genetic evidence shows that HYT1 is an important component in the transduction of oxygen-sensing, required for tolerance to acute hypoxia and other stress responses. Expression of HYT1 is directly activated by group VII ETHYLENE RESPONSE FACTOR transcription factors (ERFVIIs), that are also pathway substrates. The relationship between ERFVIIs and HYT1 has properties of a coherent feed-forward loop initiated and maintained by hypoxia, providing a mechanism to ensure robust response to reduced oxygen.
The authors' abstract, as published at the source. Nature Communications, 2026 · DOI ↗
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Field: Plant Science
Plant ScienceAgricultural and Biological Sciences