Persimmon Yan Ürünlerinin Etanol Modifiye Süperkritik CO2 Ekstraksiyonu ile Biyoaktif ve Antimikrobiyal Formülasyonlar İçin Yenilikçi Kullanımı: Pilot Seviye Kavram Kanıtlama ve Yeşil Kimya Değerlendirmesi

Özet (abstract)

Abstract This study addresses the sustainable valorization of persimmon (Diospyros kaki L.) side streams via process intensification through supercritical CO2 technology (Sc-CO2) (35 MPa, 50 °C, 120 min). Namely, the ethanol proportion in the supercritical stream and different levels of operation (LoOP) were tested. In particular, the process at a pilot LoOP (2%-ethanol-doped, 2 kg of sample) enabled the production of a lipophilic extract with enhanced nutritional and biological activity, making it a promising candidate for further research in nutraceutical formulations. More deeply, the extract demonstrated a noted antimicrobial activity against bacteria (Escherichia coli, Bacillus subtilis) and filamentous fungi (Penicillium expansum), with minimum inhibitory concentrations (MIC) ranging from 0.8-7-8 μL/mL that were similar as the benchmark (oregano extract). In addition, the crude displayed a noted Fe content (85.8 mg/100 g extract), with a relevant presence of Mg as well (up to 52% RDI in 100 g extract). The environmental sustainability of the process (pilot level, 2%-ethanol-doped) was assessed through green chemistry metrics. Namely, the protocol displayed 45.9 score in the eco-scale, and a ten-fold reduction for PMI or CEF compared to bench scale experiments (2%-ethanol). Overall, this work highlights the efficiency of an advanced methodology to produce a bioactive extract from persimmon culls that represents a promising candidate for the development of nutraceuticals.

Yazarların özeti; kaynağından alınmıştır. ACS Omega, 2026 · DOI ↗