Chemical Society Reviews· 2012Q1· Review
BODIPY dyes in photodynamic therapy
- 2,060citations
- Q1SCImago
- 2012year
Short summary
BODIPY dyes can be modified with substituents to quench fluorescence and generate long-lived triplet states, which then produce singlet oxygen for photodynamic therapy (PDT).
AI-generated from the title and abstract; the full text is not read.
Key points
- BODIPY dyes can be chemically modified to reduce fluorescence and increase triplet state generation.
- Modified BODIPY dyes produce singlet oxygen upon interaction with oxygen and light.
- Singlet oxygen generated in tissues causes localized cell damage, forming the basis of PDT.
- BODIPY dyes are promising candidates for future PDT agents, despite not being currently approved.
AI-generated from the title and abstract; the full text is not read.
Abstract
BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with (3)O(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.
The authors' abstract, as published at the source. Chemical Society Reviews, 2012 · DOI ↗
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Field: Biomedical Engineering
Biomedical EngineeringEngineering