Biomedicine & Pharmacotherapy· 2020Q1· Review
Isorhamnetin: A review of pharmacological effects
- 527citations
- Q1SCImago
- 2020year
Short summary
Isorhamnetin, found in sea buckthorn and Ginkgo biloba, demonstrates broad pharmacological activities including cardio-cerebral vascular and nerve protection, anti-tumor, anti-inflammatory, and anti-oxidant effects.
AI-generated from the title and abstract; the full text is not read.
Key points
- Isorhamnetin is a major active compound in Hippophae rhamnoides and Ginkgo biloba.
- It possesses diverse pharmacological effects including cardio-cerebral vascular protection, anti-tumor, anti-inflammatory, and anti-oxidant activities.
- Mechanisms involve regulation of PI3K/AKT/PKB, NF-κB, and MAPK signaling pathways.
- Research on isorhamnetin's detailed mechanisms and targets is currently limited.
AI-generated from the title and abstract; the full text is not read.
Abstract
• The pharmacological effects of isorhamnetin are reviewed comprehensively. • Isorhamnetin is mainly contained in Hippophae rhamnoides and Ginkgo biloba . • Isorhamnetin protects cardio-cerebral vessels and nerves. • Investigations on the mechanism of action of isorhamnetin are limited. • The research on the target of isorhamnetin is missing. Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the effects of cardiovascular and cerebrovascular protection, anti-tumor, anti-inflammatory, anti-oxidation, organ protection, prevention of obesity, etc. The related mechanisms involve the regulation of PI3K/AKT/PKB, NF-κB, MAPK and other signaling pathways as well as the expression of related cytokines and kinases. Isorhamnetin has a high value of development and application. However, the investigations on its mechanism of action are limited and lack of detailed scientific validation. The manuscript reviewed the pharmacological effects of isorhamnetin and related mechanisms of action for the development of its medicinal properties further.
The authors' abstract, as published at the source. Biomedicine & Pharmacotherapy, 2020 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Complementary and alternative medicine
Complementary and alternative medicineMedicine