BioMed Research International· 2014Q2
Phytochemical Evaluation, Antimicrobial Activity, and Determination of Bioactive Components from Leaves of<i>Aegle marmelos</i>
- 439citations
- Q2SCImago
- 2014year
Short summary
The Pant Aparna variety of Aegle marmelos leaves showed the highest concentration of alkaloids, flavonoids, and phenols, with its aqueous extract exhibiting potent antibacterial activity against S. epidermidis and methanolic extract against S. aureus at 40 mg/mL.
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Key points
- The Pant Aparna variety of Aegle marmelos leaves contained the highest levels of alkaloids, flavonoids, and phenols.
- Aqueous leaf extract of Pant Aparna was most effective against S. epidermidis.
- Methanolic leaf extract of Pant Aparna was most effective against S. aureus at 40 mg/mL.
- Minimum Inhibitory Concentrations (MIC) ranged from 10-40 mg/mL for aqueous and methanol extracts, and 40-160 mg/mL for aqueous:ethanol extracts.
- GC-MS analysis identified bioactive compounds like flavonoids, terpenoids, and phenolics contributing to antibacterial activity.
AI-generated from the title and abstract; the full text is not read.
Abstract
The therapeutic value of Aegle marmelos Correa (Rutaceae), commonly known as ''Bael," has been recognized as a component of traditional medication for the treatment of various human ailments. The plant, though, being highly explored, still lacks sufficient evidences for the best variety possessing the highest degree of medicinal values. The present study is focused on phytochemical screening of aqueous and methanolic leaf extracts of 18 varieties/accessions of A. marmelos. The crude extracts of A. marmelos revealed the presence of several biologically active phytochemicals with the highest quantity of alkaloids, flavonoids, and phenols in Pant Aparna variety. The antibacterial efficacy was investigated against pathogenic bacterial strains and the highest inhibitory activity of aqueous extract was obtained against S. epidermidis, whereas methanolic extract was found to be most potent against S. aureus at 40 mg/mL concentration. However, in aqueous : ethanol, the best results were observed against E. aerogenes followed by K. pneumonia and S. epidermidis. The MIC of aqueous and methanol extract of Aegle marmelos ranged from 10 mg/mL to 40 mg/mL whereas in aqueous : ethanol it ranged between 40 mg/mL and 160 mg/mL. The GC-MS analysis revealed the presence of many bioactive compounds such as flavonoids, alcohols, aldehydes, aromatic compounds, fatty acid methyl esters, terpenoids, phenolics, and steroids that can be postulated for antibacterial activity.
The authors' abstract, as published at the source. BioMed Research International, 2014 · DOI ↗
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Field: Complementary and alternative medicine
Complementary and alternative medicineMedicine